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Dutasteride blocks DHT more completely than finasteride (it inhibits both type I and type II 5-alpha reductase)

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Additionally, the NNMT substrate nicotinamide 12 is metabolized by the microbiome 56,57 , and thus NNMTi may modulate substrate availability, potentially influencing microbial metabolic capacity to drive the NNMTi-mediated weight loss

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DOI: 10.14740/jem211w Kwon DR & Park GY (2015) Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model Ann Clin Lab Sci 45(4):426432

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