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PMC 5827921
Elevated cAMP activates PKA, which phosphorylates/activates CREB, driving expression of MITF and MITFdependent melanogenic genes, including tyrosinase (TYR), TYRP1, and DCT/TYRP2
These three B vitamins seem to work together when it comes to the prevention of age-related macular degeneration
Why does this matter practically
Most people start to feel subtle improvements within 12 weeks
Weeks 8-12 : More significant improvements in deeper wrinkles, continued collagen density increase, improved skin thickness (measured via ultrasound in clinical settings), and sustained reduction in age-related skin laxity
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