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Serious adverse events were reported by 4.2% of participants on survodutide, compared to 6.5% of those on placebo
40 Recently, CKM syndrome has become a focus of clinical research: the importance of targeted therapy for CKD in patients with HF has even been underlined in the recent 2023 update of the European Society of Cardiology (ESC) guidelines for HF management, with SGLT2i and finerenone approved for the treatment of diabetic nephropathy to prevent HF events
Lillys pill, a small molecule, was shown to be generally safe in its trials, with the most common side effects being nausea, vomiting, and diarrhea, similar to other GLP-1 drugs
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Prompt therapy with widely available over-the-counter therapies is an initial step in treating these side effects and potentially increasing adherence to the GLP-1 regimen prescribed for Type 2 diabetes and obesity
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