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In vivo, improved cartilage repair was achieved by articular injection of MSCs with high levels of cellular GSH and MSCs cultured under high-density conditions, as confirmed by Collagen type 2 IHC, Safranin-O staining and ODriscoll scores showing that more hyaline cartilage was formed on the defects

Furthermore, the systemic neuroinflammation driven by this oxidative stress directly impacts the autonomic nervous system

Oxidative stress can induce cell damage

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(2021) The InterPro protein families and domains database: 20 years on, Nucleic Acids Res