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Variants in FTO (fat-mass and obesity-associated), GLP1R (the GLP-1 receptor gene, the direct target of every GLP-1 compound), MC4R (a melanocortin receptor central to satiety and energy balance), and TCF7L2 (a transcription factor linked to glucose homeostasis and GLP-1 secretion) map that terrain

While the ADA recommends considering a GLP-1 receptor agonist or the addition of mealtime insulin, 3 the AACE/ACE algorithm additionally recommends SGLT-2 inhibitors and DPP-4 inhibitors as potential therapies that can be added to basal insulin, if they are not already incorporated into the medication regimen

Hashash JG, Thompson CC, Wang AY

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The starting price of Ozempic has been reduced by 36%, while Wegovy has seen a steeper 48% cut