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This slowed digestive transit can have several downstream effects: it reduces the speed at which intestines move (peristalsis), and can modulate hormones and the gut-brain signals involved in nausea and satiety

These immune-mediated events were compounded by intolerable gastrointestinal side effects, including nausea in 59% and vomiting in 37% of participants, along with reports of acute pancreatitis, culminating in a dropout rate of 2634% in Phase 3 trials [65]

doi: 10.1056/NEJMoa2107519 48 LudvikBGiorginoFJdarEFriasJPFernndez LandLBrownKet al

Kidneys were removed and sliced along the corticomedullary axis

Pseudoephedrine cross-reactivity with amphetamine assays