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Obesity, insulin resistance, and type 2 diabetes: associations and therapeutic implications

DDR pathway activation phosphorylates and activates p53, which subsequently induces the expression of p21 23

Feeling tired can sometimes be part of a detoxification response as the body redirects energy toward internal repair and "cleansing." If this persists, it may be a sign that your body needs more supportive cofactors like B vitamins or that you should adjust the timing of your dose to the evening

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Experimental model for production of perforating duodenal ulcers by cysteamine in the rat

doi:10.1186/cc3742