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As a dual GIP/GLP-1 receptor agonist, it activates two metabolic pathways simultaneously, producing average weight loss of 20.9% in clinical trials
or has a history of cancer
PMID 23580036
But unlike, GLP-1, it does not quickly break down, meaning it remains active in the body for an extended period, making it a perfect candidate for a diabetes drug
Once you understand that difference, half the noise in this category disappears
What Studies Show In a Phase 2 clinical trial published in The New England Journal of Medicine , patients taking orforglipron lost significant amounts of weight across several dose ranges
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