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Expect nausea, vomiting, and possibly diarrhea lasting 48 to 72 hours
Medical conditions: Certain medical conditions, such as type 2 diabetes, may require dosage modifications
Conclusions In the STEP-HFpEF trial, semaglutide improved symptoms, physical limitations, and exercise function, and reduced inflammation, NT-proBNP, and body weight in patients with the obesity phenotype of HFpEF across the range of EF
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6 Neurohormonal Mechanisms GLP-1RAs may modulate the activity of the autonomic nervous system by shifting the balance away from sympathetic overactivation towards parasympathetic tone
increasing appetite suppression and weight loss
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