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Both prolonged-release exenatide QW and dulaglutide are weekly formulations that come in single-use devices and do not require dose selection, while semaglutide comes in a multi-dose pen where the specific dose needs to be set by the user

MT-2 is not FDA-approved and carries unresolved safety concerns, including a possible link to melanoma

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Takeaway The NEJM studies highlight CagriSema as a powerful new tool, capable of producing surgery-level weight loss in some patients

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Endocrine feedback : Chronic exposure to hexarelin may lead to desensitization or downregulation of receptor sensitivity