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Current data on 5-Amino-1MQ in humans are sparse, with most findings coming from preclinical studies

This contrasts with targets in prior nanobody design studies [Bennett et al., 2025, Mille-Fragoso et al., 2025], which were selected for therapeutic relevance rather than novelty and have appeared in a bound context in the PDB at least once, exhibiting highly similar bound interfaces (Figure 2c)