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The effect of 2.4 mg once-weekly injected semaglutide in patients with HFpEF, obesity and T2D is currently investigated in an ongoing trial STEP-HFpEF DM (Semaglutide Treatment Effect in People with obesity and HFpEF and type 2 diabetes) (64, 65)
Its use is strictly limited to in vitro laboratory work (like cell cultures) or preclinical in vivo studies in animal models
Patients start on a low dose thats gradually increased each week
A contaminated vial must be discarded
3) True excess skin (significant overhang or hanging folds) If there is a meaningful amount of extra skin that cannot contract, surgery may be the only definitive option
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