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These models, however, do not include lipolysis and the control of lipolysis by insulin

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This research is particularly relevant given the rising global prevalence of cardiovascular diseases

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Because pegvisomant targets the GHR instead of GH, it results in reduced IGF1 and enhanced GH levels through the negative-feedback loop

Hormonal influences play a significant role, with estrogen affecting fat distribution, blood flow, and connective tissue structure