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Furthermore, results in NS workers support a role for vitamin D in regulating circadian gene expression, while also interacting with estrogen pathways, inflammatory signaling, and sleep quality 247,248

Current trials are investigating MEK inhibitors, immunotherapy combinations, EZH2 inhibitors, and liquid biopsy-based surveillance for early detection.

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10.1016/j.biomaterials.2012.12.009 Biomaterials 7 CharlierE.DeroyerC.CiregiaF.MalaiseO.NeuvilleS.PlenerZ.et al (2019)

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Highlighting the therapeutic implications of these findings, in utero antioxidant therapy stabilized RUNX2 and improved bone development in the Runx2+/ haplo-insufficient mouse model of human cleidocranial dysplasia