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Matfin G, Van Brunt K, Zimmermann AG, Threlkeld R, Ignaut DA

V., Agers, H., Jusko, W

Indeed, in pre-clinical models, retatrutide, a triple agonist (GLP-1/GIP/glucagon), resulted in greater WL and improved glucose profile compared to tirzepatide through increased energy expenditure and reduced calorie intake [80, 81]

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Looking forward, the integration of stimuli-responsive release mechanisms (e.g., pH-sensitive platinum coordination or ROS-triggered ligand cleavage) may further enhance therapeutic indices [105]