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In one study, the administration of IGF-1 to rats with diabetic cardiomyopathy produced several beneficial effects, including a reduction in myocardial apoptosis, oxidative stress, inflammation, interstitial fibrosis, and metabolic irregularities

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This study also showed a strong correlation between high levels of AGEs and elevated glycated hemoglobin, or hemoglobin A1C a blood test that reflects average blood sugar levels over a 60- to 90-day period by measuring the amount of hemoglobin that has undergone glycation (Jakus 2014

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