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GLP-1 is normally secreted by L cells of the gastrointestinal mucosa in response to a meal

The decline reduces sirtuin activity and sirtuins are the proteins that, when active, support healthy gene expression, metabolic flexibility and inflammatory balance

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These short peptides regulate key processes such as cell migration, proliferation, and differentiation, while also modulating inflammation, promoting angiogenesis, and facilitating extracellular matrix (ECM) remodeling