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doi:10.1093/brain/120.1.141 125. Zhang, Q., Weber, M

Abbreviations: SQS: squalene synthase

Total plasma cholesterol was also lower

Because these agents inhibit transmission in both sympathetic and parasympathetic ganglia, physiological effects reflect blockade of the predominant resting autonomic tone, including tachycardia (cardiac) and marked orthostatic hypotension (vascular) (middle panel)