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Mice were assigned to respective study groups to comprehensively evaluate multiple medical weight loss approaches with various controls: 1) vehicle (Veh, sterile water) as control, 2) SEMA to induce weight loss using semaglutide, 2) WM-CR to induce weight loss by caloric restriction to match weight loss in SEMA, 3) continuous RETA to induce weight loss, or 4) short-term RETA to induce weight loss then regain, termed RETA withdrawal (RETA-w/d)
Meds modify microbiome, mediating their effects
cheaper care means vague pricing, hidden fees, or weaker clinical oversight
Natural levels drop due to age, stress, and toxins
Large trials showed benefits that extended beyond weight alone
This is partly why theyre so effective at reducing appetite, but it also means constipation is a very common side effect
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