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Despite their critical role, there are relatively few E1-activators compared to the vast array of E3 ligases

doi: 10.1016/j.pharmthera.2023.108411 75 GrahamLSParhamiFTintutYKitchenCMDemerLLEffrosRB

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Neaime, S

Additionally, for diabetic patients, the difficulty in managing blood sugar levels can lead to acute complications such as diabetic ketoacidosis (DKA) or hyperosmolar hyperglycemic state (HHS), both of which can be fatal if not promptly treated

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