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Nonetheless, guiding NPs to reach the entire area affected by the pathology without spreading into adjacent healthy tissues is still problematic, often requiring extensive optimization of NPs physiochemical properties (size, charge, stiffness, etc.) (76)

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7A, C), to an extent ( p = 0.20)

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Protocols vary, but some practitioners recommend injections every 2-3 days instead of daily, adjusting the dose accordingly