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In the book, Kessler acknowledges that you can't really separate those unpleasant feelings from the effective mechanism of the drugs themselves
Weight change in the placebo group was 3.1% (95% CI, 4.3 to 1.9)
Cells 14 , 376 (2025)
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Because of this, it probably does a better job in clinical trials at controlling blood sugar and promoting weight loss
GLP-1 agonists were first developed for type 2 diabetes, but several are now approved and widely used for weight management in people without diabetes
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