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They mention engineering stability (to survive stomach acid and enzymes) and transport (to cross the gut lining)
A., Kabir, M., Hossain, M
7.2 Integration of multi-omics approaches We proposed that future research should combine metagenomics, metabolomics, and transcriptomics to better elucidate the complex interactions between gut microbiota alterations and hepatic metabolic dysfunction in cadmium-induced liver injury
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