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Key takeaways for mums: GLP-1 medications are not safe to take while breastfeeding

In the Post-Anesthesia Care Unit (PACU) Youll be in the PACU when you wake up after your surgery

Glucagon enhances multiple steps in this pathway: Increased lipolysis: Glucagon activates hormone-sensitive lipase in adipose tissue, releasing more fatty acids into circulation Reduced lipogenesis: Glucagon suppresses the enzymes responsible for creating new fat from carbohydrates Enhanced hepatic oxidation: Glucagon upregulates liver enzymes involved in fatty acid oxidation Ketogenesis: When fat oxidation exceeds the citric acid cycle capacity, excess acetyl-CoA is converted to ketone bodies, an alternative fuel source The net effect is a metabolic state favoring fat breakdown over fat storage

Nissen, who serves as study co-chair of SURMOUNT-MMO, notes that the exclusion of patients with diabetes will avoid confounding of results by favorable outcomes due to tirzepatides antidiabetic effects

Watch-out: Monthly medication costs ($149-$224 for compounded) are mid-range, not the cheapest available

Many people who use them talk about how their "hunger noise" is less, and they find it easy to eat smaller meals or eat less often