A large JAMA Network Open study of more than 1.6 million people with type 2 diabetes found that GLP-1 RAs were associated with a significantly lower risk of 10 of 13 obesity-related cancers compared with insulin , but no clear advantage over metformin , and a higher risk of kidney cancer vs metformin
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For researchers choosing between the two most potent compounds in this class, retatrutide currently shows a 1.52 percentage-point weight-loss advantage over tirzepatide at comparable durations, but tirzepatide carries substantially more Phase 3 evidence and a confirmed MHRA authorisation [1][2]
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The E3 ubiquitin ligase Pellino3 protects against obesity-induced inflammation and insulin resistance
Kidney Concerns Semaglutide does not directly damage the kidneys, but severe vomiting or diarrhea can lead to dehydration