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Table 2: Potential Effects of GLP-1 in Arthritis GLP-1 receptor agonists show anti-inflammatory and cartilage-protective effects , though mechanisms are still under investigation
The safety story is promising , but not fully settled from a topline release alone
The immune system responds to the dramatic changes in energy balance with increased inflammatory signaling
Heres the bottom line-for many self-pay patients, the Wegovy pill may be the more affordable Wegovy option, especially early in treatment when youre stepping up doses
In both patient populations with pre-existing cardiovascular disease, DPP-4 inhibitors are recommended as one possible third-line therapy besides SGLT-2 inhibitors, thiazolidinediones, or insulin, when therapeutic goals are not met with the previous dual combination
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