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Downstream effects include concentration-dependent suppression of lipogenesis (50-70% reduction), decreased adipocyte size, and increased basal energy expenditure without appetite suppression
This allows internalized NADs to dissociate from the fusogenic peptide delivery system and escape into the cytoplasm to exert their therapeutic effects
Interestingly, emerging evidence suggests that GLP-1RAs may also provide therapeutic behavioral modification beyond their effects on appetite and food preferences
Selective androgen receptor modulators (SARMs), like ostarine and ligandrol, are similarly restricted
doi:10.1016/j.heliyon.2024.e27471
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