They can enlarge, regress or involute (disappear)
Moreover, for a metabolite to serve as a clinically useful biomarker, it must demonstrate both sensitivity and specificity for a particular disorder
10.1152/jappl.1996.80.1.149 276 SerebrovskaZ.SwansonR.PortnichenkoV.ShyshA.PavlovichS.TumanovskaL.et al (2017)
Ziauddeen H, Alonso-Alonso M, Hill JO, Kelley M, Khan NA (2015) Obesity and the neurocognitive basis of food reward and the control of intake
Your body already makes GLP-1, here's how to make more of it
Groop PH, Dandona P, Phillip M et al (2020) Effect of dapagliflozin as an adjunct to insulin over 52 weeks in individuals with type 1 diabetes: post-hoc renal analysis of the DEPICT randomised controlled trials