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In preclinical models of polymicrobial sepsis, such as the cecal slurry and cecal ligation puncture (CLP) models, long-acting GLP-1 receptor agonists (GLP-1RAs) like semaglutide have demonstrated protective effects

While this simplifies the dosing regimen and reduces the chance of errors, separate bottles allow for more flexible tapering of individual medications

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The situation gets especially tricky for older Americans