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44, 77 Methymalonic acid, a metabolite of PPA, results in abnormal mitochondrial morphology, 78 tissue specific ETC dysfunction, 79 inhibition of the complex I and II function when interacting with complex III in the brain 80 and reductions in reduced glutathione, 78 similar to the patient cohort presented and the PPA animal model

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Thats exactly the problem Lemme Metabolism was formulated to solve. One of its key components is Akkermansia muciniphila, a postbiotic associated with gut barrier integrity and metabolic function

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3538 Exosomes are small and can cross the bloodbrain barrier (BBB)