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J Clin Endocrinol Metab 100(11):40374047

Kidney Protection Through Reduction Of Oxidative And Chemical Stress The kidneys are constantly exposed to metabolic waste, drugs, and contrast agents used in medical imaging

doi:10.1111/j.1445-5994.1989.tb00349.x

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In the SURMOUNT-1 study, a phase 3 clinical trial in obese patients, randomized participants in a 1:1:1:1 ratio to tirzepatide (5, 10, 15 mg) or placebo over 72 weeks, significant weight reductions were observed at 72 weeks: 15.0% for 5 mg, 19.5% for 10 mg, 20.9% for 15 mg, compared to 3.1% for placebo [18]