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Notably, compound 1d exhibited the most potent activity against Escherichia coli and Staphylococcus aureus with MIC ranges of 31.3125.0 g/mL and against Pseudomonas aeruginosa with MIC ranges of 375.0500.0 g/mL
No lethal dose was reached in preclinical toxicology studies, and no significant adverse effects have been reported in published research
Pu A-Y, Huang Y-L, Pu C-M, Kang Y-N, Hoang KD, Chen K-H, et al
Glucagon Receptor Effects become particularly interesting with Survodutide because of the compounds enhanced liver effects
(5) Yanqing Li, Chi Zhang, Haicheng Cheng, LinYan Lv, Xinning Zhu, Menghui Ma, Zhenhan Xu, Junxian He, Yun Xie, Xing Yang, Xiaoyan Liang, Chunhua Deng, Guihua Liu, FOXO4-DRI improves spermatogenesis in aged mice through reducing senescence-associated secretory phenotype secretion from Leydig cells, Experimental Gerontology, Volume 195, 2024, 112522
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