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The study was funded largely by the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health. It was published December 10, 2018 in the European Heart Journal
Despite its growing popularity among athletes and its wide availability through non-regulated sources, there is minimal human data available
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The accumulation of potentially toxic acyl species or imbalances in acylcarnitine profiles within the immature intestine might play a role in such injury pathways
Our study reveals that autopalmitoylation, conferred by the IDH1 R132H mutation, links fatty acid metabolism to the regulation of IDH1 mutant activity and represents a druggable vulnerability in IDH1 -mutant cancers
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