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2.5 Dosing in Patients with Renal Impairment In patients with renal impairment (creatinine clearance less than 70 mL/min/1.73 m2), one-half of the usual adult dose of TOPAMAX is recommended [see Use in Specific Populations (8.5, 8.6), Clinical Pharmacology (12.3)]
Multiple human trials show reductions in fasting blood glucose and improvements in glucose tolerance when fenugreek is taken regularly
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