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In HF with preserved ejection fraction (HFpEF), GLP-1 RAs may not reduce HF hospitalization but might lower atherosclerotic event risks [66, 67]
It reflects a broader shift toward treating obesity with the same level of care and understanding as other chronic diseases
Moreover, the administration of these peptides to healthy individuals for anti-aging or performance enhancement introduces additional ethical and safety considerations, as the long-term effects of chronic exposure in otherwise healthy populations remain unknown
Sip Fluids if Tolerated Small amounts may be easier than chugging
Contact your GP if you experience severe or worsening fatigue impairing daily activities, symptoms of hypoglycaemia (especially if taking insulin or sulphonylureas), signs of dehydration, severe abdominal pain, or fatigue accompanied by other concerning symptoms such as unexplained weight loss, fever, or mood changes
Secondary endpoints included percent change in body weight from baseline to 36 weeks, absolute changes in body weight, BMI and waist circumference at 26 and 36 weeks, and the percentage of adults with at least a 5% and 10% weight loss at 26 and 36 weeks
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