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Interestingly, reintroducing cytoplasmic GPX4, rather than its mitochondrial or nuclear counterparts, can rescue the lethal phenotype in Gpx4 -null mice [119]

The mitochondrial FH enzyme is involved in the citric acid cycle, and the cytoplasmic FH enzyme is involved in the urea cycle, tyrosine catabolism, and purine de novo synthesis (Fig

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