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Systems constituting special chemical linkages like peptides, esters, glycosidic bonds, disulfides, or azo bonds can undergo physical or chemical degradation in response to changes in the expression of specific enzymes 44,45

Multi-omics integration helps identify cross-layer programs and reduces reliance on any single noisy measurement [15]

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This offers a balanced mix that aids recovery

Peptides in excess of 18 residues begin to present more synthetic challenges

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