Lung tumors show higher BCAAs uptake than PDAC
Besides Gpx1, Gpx4 displays preference for lipid hydroperoxides ( Figure 3 ), and hence plays a key role in protecting phospholipids, cholesteryl esters and cardiolipin and defense against apoptosis and maintenance of ETC and OXPHOS (Cole-Ezea et al., 2012)
Despite promising preclinical results with inhibitors (e.g., ferrostatin-1) and gene therapies targeting GPX4/ACSL4, clinical translation faces critical barriers: the poorly defined temporal dynamics of ferroptosis post-stroke hinders therapeutic window optimization, and its interplay with necroptosis/pyroptosis requires clarification to guide combination therapies
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