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The copper ion in GHK-CU serves multiple functions beyond its role as a cofactor
In 2017, Tang's group showed that heat shock 70-kDa protein 5 (HSPA5) negatively regulated ferroptosis in human pancreatic ductal adenocarcinoma (PDAC) cells through the HSPA5-GPX4 pathway (Zhu et al., 2017)
Notably, research using a murine MRSA pneumonia model suggests that inducing MRSA death via ferroptosis characteristics can enhance mouse survival rates, reduce bacterial loads, and mitigate inflammatory damage, offering promising clinical therapeutic implications ( S
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