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0.33g of the crude Boc-His (Trt) -Aib-OSu and 1g of the compound 2 obtained in example 2 were dissolved in 20mL of N, N-dimethylformamide, and 2mL of N, N-diisopropylethylamine was added and reacted at room temperature for 8 hours to obtain compound 4 having a purity of 76.13%, and a specific liquid phase diagram is shown in FIG

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If patients are considering discontinuation, it should ideally be done gradually with close clinical monitoring rather than abruptly

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