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In the drugs best showing so far, the ATTAIN-1 trial, people taking orforglipron lost on average 12.4% of their baseline weight, a notch below the roughly 14% weight loss seen in similar trials of Novo Nordisks injectable Wegovy and also below the typical results seen with Eli Lillys tirzepatide, a dual GLP-1/GIP medication

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Drug misuse* involves taking a drug for nonmedical purposes, or in a way thats not approved

Phase 3 ESSENCE Trial: Semaglutide in Metabolic Dysfunction-Associated Steatohepatitis [PMID: 39896971] Laboratory literature summary: Phase 3 ESSENCE Trial: Semaglutide in Metabolic Dysfunction-Associated Steatohepatitis

Peptides are one arrow in that quiver along with lifestyle, nutrition, stress, and medical interventions