Tirzepatide is a newer, dual-action molecule (acting on both GLP-1 and GIP receptors), and its base ingredients are currently more costly to produce
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Three dual agonists (peptide 15, MEDI0382 and SAR425899) and one triple agonist (peptide 20) were evaluated at GLP-1R and GCGR, relative to the native peptidic ligands (GLP-1 and glucagon)
Who Should Avoid It
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The verdict: If you have insurance, pursue Ro first