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Combination of hyaluronidase and other immunotherapeutic drugs Although the clinical application of immune checkpoint inhibitors is in full swing, there are still many tumors for which immunotherapy still fails to achieve satisfactory therapeutic effects, the emergence of small molecules has made up for some of the shortcomings of immunotherapy [280]
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The practical consequence is that claims should be attributed to the right tier
TB-500 (Thymosin Beta-4) : A 43-amino acid actin-sequestering peptide that promotes tissue regeneration through cell migration, angiogenesis (via VEGF upregulation), and anti-inflammatory effects
Excessive mitochondrial fission is believed to enhance fibroblast proliferation and collagen production, likely because mitochondrial fission acts downstream of TGF-1 [74]
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