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10.1016/j.molmet.2017.08.010 225

Increased appetite resulting from the catabolic state caused by insulin deficiency and breakdown of proteins and fats

Neither has published long-term hard-outcome data such as cardiovascular events or mortality, which is the kind of evidence that ultimately defines a metabolic drugs value

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Since they do not require FDA approvals, compounded variants bypass premarket efficacy and safety reviews

While the medication is not contraindicated in IBD, careful monitoring may be warranted to distinguish disease flares from medication-related effects