Melanotan I (afamelanotide) is sold under the brand name Scenesse and is approved in the European Union for erythropoietic protoporphyria (EPP), a condition where sunlight exposure causes severe pain
Interestingly, this enzyme enhances cysteine starvation-induced ferroptosis through activation of the GCN2-eIF2-ATF4 pathway in human triple negative breast cancer cells (60)
Inhibition of brain CPT-1 decreases the entry of fatty acid carbons into the aqueous metabolic pools but does not alter the distribution into various long-chain acyl-CoA compounds and triglycerides
Given the shared underlying mechanisms of various EDs, it is essential to investigate the potential therapeutic effects of GLP-1 analogs for other EDs, particularly those associated with binge eating or EE
In May 2026, At the EASL Congress 2026, MetaVia presented promising late-breaking Phase 1 clinical trial results for DA-1726, an investigational dual GLP-1 and glucagon receptor agonist under development for obesity and Metabolic Dysfunction-Associated Steatohepatitis (MASH)
Example: If your pre-meal reading is typically 145 mg/dL (8.0 mmol/L) and your 2-hour after-meal reading is 210 mg/dL (11.7 mmol/L), these are above target