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An example of an NO prodrug is O 2 -(2,4-dinitrophenyl)1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate (JS-K), devised by Keefer et al from the National Cancer Institute

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Earlier ambitious but futile attempts to develop these non-peptide drugs have been reviewed in detail elsewhere [10,38]

This question echoes in the minds of many health enthusiasts, as timing and method can significantly impact the effectiveness of any supplement