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All patients had documented serum 25-hydroxyvitamin D [25(OH)D] levels prior to treatment initiation

Chromatin Decondensation: It binds to specific histone proteins (H1/3, H1/6), relaxing condensed chromatin (heterochromatin)

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[1] Observed mass-spectrometric signals can vary with charge state, adduct formation, isotope distribution, ionization conditions, and data processing

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