Oral glutathione supplements have poor bioavailability, meaning the body lacks an efficient method of absorbing the compound for use
These clinical effects are certainly impressive in themselves, but the hype around these drugs can only be fully understood by considering the demographic trends which they may help address
While the gastrointestinal effects (nausea, diarrhea, vomiting) are similar to other GLP-1 medications like Wegovy and Mounjaro, retatrutide has one unique finding: dysesthesia (abnormal touch sensations) in 20.9% of patients at the 12mg dose in TRIUMPH-4, and 12.5% at 12mg in the larger TRIUMPH-1 trial
Acarbose, lente carbohydrate, and prebiotics promote metabolic health and longevity by stimulating intestinal production of GLP-1
doi: 10.1172/JCI72434 143 OrskovCPoulsenSSMllerMHolstJJ
Fotouhi A, Hagos WW, Ilic M, Wojcik A, Harms-Ringdahl M, de Gruijl F, et al