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doi: 10.1016/j.bbrc.2017.11.114 145 YoonGKimYKSongJ
Increased FFA in the liver results in insulin resistance, hepatic glucose production, and pancreatic beta cell dysfunction [7]
Patients with T2DM experience a significant decline in the incretins functional properties which causes delayed and reduced insulin release after glucose administration and impairs glucose tolerance [12,13,14]
Ongoing research includes: long-term pancreatic studies thyroid cancer surveillance 5-year cardiovascular follow-ups GI motility research safety monitoring for chronic users registries for severe GLP-1 complications FDA GLP-1 Warnings When to Call a Doctor Immediately Seek medical attention if you experience: severe abdominal pain persistent vomiting dehydration rapid weight loss inability to eat jaundice sharp back or flank pain little or no urine output These may indicate long-term GI damage, pancreatitis, or kidney injury
Clinical effectiveness of exenatide in diabetic patients waiting for bariatric surgery
In contrast to GIP, GLP-1 was found to retain its insulinotropic effect in patients, and this fact provides part of the background for the clinical use of GLP-1 receptor agonists in diabetes treatment
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