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In some cases, combining hormone therapy with a GLP-1 medication may help preserve muscle and improve fat loss during menopause

Tirzepatide, a dual GIP/GLP-1 receptor agonist, has shown even greater efficacy in some studies, with weight reductions of approximately 20% in the SURMOUNT-1 trial

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Compared to the double-digit weight loss percentages seen in GLP-1 RA studies, phentermine appears to generate just 1-3% weight loss after six months.14 Topiramate may add a modest influence on insulin to the picture, which could account for its superior performance (at least according to an animal study).15 Topiramate studies typically see closer to 10% body weight reduction after a year of use.16 Testosterone replacement therapy (TRT) Henry offers two drugs intended to treat low testosterone: testosterone cypionate injections and testosterone cream

Side Effects Nausea Vomiting Diarrhea Constipation Bloating Indigestion Stomach pain Burping These side effects usually occur when you first start the medication or increase the dose, but tend to improve as your body adjusts, says Connor